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Therapeutic potential of α-and β-pinene: A miracle gift of nature
journal contributionposted on 2023-02-21, 04:54 authored by B Salehi, S Upadhyay, IE Orhan, AK Jugran, SLD Jayaweera, DA Dias, F Sharopov, Y Taheri, N Martins, N Baghalpour, WC Cho, J Sharifi-Rad
α-and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α-and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.