Therapeutic potential of α-and β-pinene: A miracle gift of nature
Version 3 2024-06-19, 17:39Version 3 2024-06-19, 17:39
Version 2 2024-06-06, 04:48Version 2 2024-06-06, 04:48
Version 1 2023-02-21, 04:54Version 1 2023-02-21, 04:54
journal contribution
posted on 2024-06-19, 17:39authored byB Salehi, S Upadhyay, IE Orhan, AK Jugran, SLD Jayaweera, Dan DiasDan Dias, F Sharopov, Y Taheri, N Martins, N Baghalpour, WC Cho, J Sharifi-Rad
α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.