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Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?

journal contribution
posted on 2007-12-01, 00:00 authored by A L Albiston, G R Peck, H R Yeatman, R Fernando, Siying Ye, S Y Chai
Insulin-regulated aminopeptidase, IRAP, is an abundant protein that was initially cloned from a rat epididymal fat pad cDNA library as a marker protein for specialized vesicles containing the insulin-responsive glucose transporter GLUT4, wherein it is thought to participate in the tethering and trafficking of GLUT4 vesicles. The same protein was independently cloned from human placental cDNA library as oxytocinase and is proposed to have a primary role in the regulation of circulating oxytocin (OXY) during the later stages of pregnancy. More recently, IRAP was identified as the specific binding site for angiotensin IV, and we propose that it mediates the memory-enhancing effects of the peptide. This protein appears to have multiple physiological roles that are tissue- and domain-specific; thus the protein can be specifically targeted for treating different clinical conditions.

History

Journal

Pharmacology & therapeutics

Volume

116

Issue

3

Pagination

417 - 427

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0163-7258

eISSN

1879-016X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2007, Crown Copyright