armitage-threedimensional-2014.pdf (2.39 MB)
Three-dimensional numerical simulation of blood flow in mouse aortic arch around atherosclerotic plaques
journal contribution
posted on 2014-09-01, 00:00 authored by P Assemat, James ArmitageJames Armitage, K K Siu, K G Contreras, A M Dart, J P Chin-Dusting, K HouriganAtherosclerosis is a progressive disease, involving the build-up of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is critically important since plaque rupture can result in heart attack or stroke. Plaques can be divided into two distinct types: those likely to rupture (vulnerable) or less likely to rupture (stable). In the last decade, researchers have been interested in studying the influence of the mechanical effects (blood shear stress, pressure forces and structural stress) on the plaque formation, progression and rupture processes but no general agreement has been found. The purpose of the present work is to include more realistic conditions for the numerical calculations of the blood flow by implementing real geometries with plaques in the numerical model. Hemodynamical parameters are studied in both diseased and healthy configurations. The healthy configuration is obtained by removing numerically the plaques from three dimensional geometries obtained by micro-computed tomography. A new hemodynamical parameter is also introduced to relate the location of plaques to the characteristics of the flow in the healthy configuration. © 2014 .
History
Journal
Applied Mathematical ModellingVolume
38Issue
17-18Pagination
4175 - 4185Publisher
ElsevierLocation
New York, United StatesPublisher DOI
Link to full text
ISSN
0307-904XLanguage
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2014, ElsevierUsage metrics
Keywords
Atherosclerotic plaquesMechanical effectsOscillating flowPlaque progressionPressure gradientWall shear stressScience & TechnologyTechnologyPhysical SciencesEngineering, MultidisciplinaryMathematics, Interdisciplinary ApplicationsMechanicsEngineeringMathematicsWALL SHEAR-STRESSCAROTID BIFURCATIONHEMODYNAMICSARTERYVULNERABILITYTOMOGRAPHYMECHANISMTRANSPORTATHEROMALOCATIONArtificial Intelligence and Image Processing
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