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Tissue distribution of lignans in rats in response to diet, dose−response, and competition with isoflavones
journal contribution
posted on 2007-01-01, 00:00 authored by T Murray, J Kang, Lee AstheimerLee Astheimer, W PriceThis paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END) and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues by use of liquid chromatography−electrospray ionization mass spectrometry (LC−ESI/MSn) following a variety of dietary regimes. Furthermore, we examined the dose−response and distribution of END and ENL in liver, testes, prostate, and lung, and we investigated the effects of competition between lignans and isoflavones on metabolite distribution. In liver, testes, prostate, and lung tissue, dose-related increases in END concentration were observed. In the testes, coadministration of 60 mg/kg secoisolariciresinol diglycoside (SDG) with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile, causing increased END concentration and decreased DAID concentration. Results indicate lignan accumulation in tissues occurs, and coadministration of lignans with isoflavones affects the metabolite profile, with effects dependent on tissue type.
History
Journal
Journal of agricultural and food chemistryVolume
55Issue
12Pagination
4907 - 4912Publisher
American Chemical SocietyLocation
Columbus, OhioPublisher DOI
ISSN
0021-8561eISSN
1520-5118Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, American Chemical SocietyUsage metrics
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