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To cooperate or not: the role of central functionality in bisthiourea [6]polynorbornane hosts

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journal contribution
posted on 2024-06-04, 02:35 authored by RN Robson, BP Hay, Fred PfefferFred Pfeffer
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Using fused [n]polynorbornane scaffolds functionalised at each end with a thiourea recognition unit a series of anion hosts of increasing length were constructed. The three longest [6]polynorbornyl hosts possessed central functionality to influence the binding cleft. The functional groups comprised (i) two methyl esters (ii) an unfunctionalised imide to introduce an additional N–H hydrogen-bond donor and (iii) a large p-anisole group to provide negative steric interactions. The family of bisthiourea hosts were evaluated for their ability to bind five aromatic dicarboxylate guests of varying shapes and lengths.

History

Journal

European journal of organic chemistry

Volume

2019

Pagination

6720-6727

Location

Chichester, Eng.

Open access

  • Yes

ISSN

1434-193X

eISSN

1099-0690

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Issue

39

Publisher

Wiley