Deakin University
Browse

File(s) under permanent embargo

To investigate dose reduction and comparability of standard dose CT vs Ultra low dose CT in evaluating pulmonary emphysema

journal contribution
posted on 2019-01-01, 00:00 authored by Ciara O'Brien, Terry Kok, Brendan Kelly, Kanako Kumamaru, Abhilash Sahadevan, Stephen Lane, Orla Buckley
OBJECTIVES: The aim of this study was to investigate the extent of dose reduction and comparability of standard dose CT vs Ultra low dose CT in evaluating pulmonary emphysema. METHODS: Forty-nine patients with emphysema were recruited from a tertiary referral respiratory clinic. Each patient had a non-contrast Standard Dose (SD) and Ultra Low Dose (ULD) thoracic CT. The images were reconstructed using contemporary iterative reconstruction with a standard lung kernel. Lung volumes and emphysema severity was calculated using a commercially available automated densitometry segmentation package. The effective dose was calculated for both CT protocols. RESULTS: Automated densitometry calculated the total lung volume and percentage lung area of emphysema. The findings were highly comparable between ULD and SD protocols. A strong correlation was seen between ULD and SD images in measurement of total lung volume (R = 0.925, p < 0.001) and percentage lung involvement by densitometry (R = 0.940, p < 0.001). There is a 95% dose reduction with the ULD protocol, the mean effective dose is 0.12 ± 0.09 mSv versus 2.33 ± 1.54 mSv for the SD protocol. CONCLUSIONS: ULD thoracic CT is a comparable protocol for the assessment of emphysema severity relative to standard dose CT. ULD CT is performed at a 95% dose reduction compared to SD CT.

History

Journal

Clinical imaging

Volume

53

Pagination

115 - 119

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0899-7071

eISSN

1873-4499

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Elsevier

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC