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Toward Immunocompetent 3D Skin Models

journal contribution
posted on 2024-09-20, 03:34 authored by A Pupovac, B Senturk, C Griffoni, K Maniura-Weber, M Rottmar, Sally McArthurSally McArthur
Abstract3D human skin models provide a platform for toxicity testing, biomaterials evaluation, and investigation of fundamental biological processes. However, the majority of current in vitro models lack an inflammatory system, vasculature, and other characteristics of native skin, indicating scope for more physiologically complex models. Looking at the immune system, there are a variety of cells that could be integrated to create novel skin models, but to do this effectively it is also necessary to understand the interface between skin biology and tissue engineering as well as the different roles the immune system plays in specific health and disease states. Here, a progress report on skin immunity and current immunocompetent skin models with a focus on construction methods is presented; scaffold and cell choice as well as the requirements of physiologically relevant models are elaborated. The wide range of technological and fundamental challenges that need to be addressed to successfully generate immunocompetent skin models and the steps currently being made globally by researchers as they develop new models are explored. Induced pluripotent stem cells, microfluidic platforms to control the model environment, and new real‐time monitoring techniques capable of probing biochemical processes within the models are discussed.

History

Journal

Advanced Healthcare Materials

Volume

7

Article number

ARTN 1701405

Location

Germany

ISSN

2192-2640

eISSN

2192-2659

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

12

Publisher

WILEY