Toward a skin-material interface with vacuum-integrated capped macroporous scaffolds
Version 2 2024-06-03, 16:35Version 2 2024-06-03, 16:35
Version 1 2016-03-30, 17:57Version 1 2016-03-30, 17:57
journal contribution
posted on 2024-06-03, 16:35 authored by GD Stynes, GK Kiroff, WA Morrison, Richard PageRichard Page, MA KirklandAvulsion, epidermal marsupialization, and infection cause failure at the skin-material interface. A robust interface would permit implantable robotics, prosthetics, and other medical devices; reconstruction of surgical defects, and long-term access to blood vessels and body cavities. Torus-shaped cap-scaffold structures were designed to work in conjunction with negative pressure to address the three causes of failure. Six wounds were made on the backs of each of four 3-month old pigs. Four unmodified (no caps) scaffolds were implanted along with 20 cap-scaffolds. Collagen type 4 was attached to 21 implants. Negative pressure then was applied. Structures were explanted and assessed histologically at day 7 and day 28. At day 28, there was close tissue apposition to scaffolds, without detectable reactions from defensive or interfering cells. Three cap-scaffolds explanted at day 28 showed likely attachment of epidermis to the cap or cap-scaffold junction, without deeper marsupialization. The combination of toric-shaped cap-scaffolds with negative pressure appears to be an intrinsically biocompatible system, enabling a robust skin-material interface. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.
History
Journal
Journal of Biomedical Materials Research - Part B Applied BiomaterialsVolume
105Pagination
1307-1318Location
United StatesPublisher DOI
ISSN
1552-4973eISSN
1552-4981Language
EnglishPublication classification
C Journal article, C1 Refereed article in a scholarly journalCopyright notice
2016, Wiley PeriodicalsIssue
5Publisher
WILEYUsage metrics
Categories
Keywords
Science & TechnologyTechnologyEngineering, BiomedicalMaterials Science, BiomaterialsEngineeringMaterials Sciencecell-material interactionsimplant designimplant interfacepercutaneousscaffoldsDERMAL REGENERATION TEMPLATESELF-ASSEMBLED MONOLAYERSTITANIUM FIBER MESHSUBATMOSPHERIC PRESSURERECONSTRUCTIVE SURGERYPERCUTANEOUS IMPLANTSCOVALENT ATTACHMENTPOROUS POLYETHYLENEPROSTHETIC PYLONPORCINE SKIN090399 Biomedical Engineering not elsewhere classified970111 Expanding Knowledge in the Medical and Health SciencesSchool of MedicineInstitute for Frontier Materials4003 Biomedical engineering
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