Deakin University
Browse
caeyenberghs-traininginduced-2015.pdf (854.85 kB)

Training-induced improvements in postural control are accompanied by alterations in cerebellar white matter in brain injured patients

Download (854.85 kB)
journal contribution
posted on 2015-01-01, 00:00 authored by D Drijkoningen, Karen CaeyenberghsKaren Caeyenberghs, I Leunissen, C Vander Linden, S Sunaert, J Duysens, S P Swinnen
© 2014 The Authors. Published by Elsevier Inc. We investigated whether balance control in young TBI patients can be promoted by an 8-week balance training program and whether this is associated with neuroplastic alterations in brain structure. The cerebellum and cerebellar peduncles were selected as regions of interest because of their importance in postural control as well as their vulnerability to brain injury. Young patients with moderate to severe TBI and typically developing (TD) subjects participated in balance training using PC-based portable balancers with storage of training data and real-time visual feedback. An additional control group of TD subjects did not attend balance training. Mean diffusivity and fractional anisotropy were determined with diffusion MRI scans and were acquired before, during (4 weeks) and at completion of training (8 weeks) together with balance assessments on the EquiTest® System (NeuroCom) which included the Sensory Organization Test, Rhythmic Weight Shift and Limits of Stability protocols. Following training, TBI patients showed significant improvements on all EquiTest protocols, as well as a significant increase in mean diffusivity in the inferior cerebellar peduncle. Moreover, in both training groups, diffusion metrics in the cerebellum and/or cerebellar peduncles at baseline were predictive of the amount of performance increase after training. Finally, amount of training-induced improvement on the Rhythmic Weight Shift test in TBI patients was positively correlated with amount of change in fractional anisotropy in the inferior cerebellar peduncle. This suggests that training-induced plastic changes in balance control are associated with alterations in the cerebellar white matter microstructure in TBI patients.

History

Journal

NeuroImage: Clinical

Volume

7

Pagination

240 - 251

Publisher

Elsevier

Location

Amsterdam, The Netherlands

eISSN

2213-1582

Language

eng

Publication classification

C1 Refereed article in a scholarly journal