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Trait and state anxiety is marked by increased working memory-related parietal BOLD signal

Version 2 2024-06-05, 03:39
Version 1 2019-06-27, 14:27
journal contribution
posted on 2024-06-05, 03:39 authored by Talitha FordTalitha Ford, T Simpson, G McPhee, C Stough, LA Downey
Anxiety is associated with compromised cognitive control functions, such as working memory. State and trait anxiety within the non-clinical population can be utilised to investigate potential neural markers for anxiety, which may help to elucidate potential prevention and intervention methods. Thirty-two healthy adults (20 female, 12 male), aged between 30 and 65 years, performed a 2-back task whilst fMRI BOLD signal was acquired using a 3T scanner. Mean BOLD signal was obtained in cognitive control network regions of interest of: left and right dorsolateral prefrontal cortex (DLPFC) and posterior parietal lobe (PPL), and medial prefrontal cortex (MPFC). State and trait anxiety levels were recorded. Higher overall anxiety was moderately associated with more left and right PPL BOLD signal; there was a weak relationship between anxiety and left DLPFC BOLD signal. MPFC BOLD signal and trait anxiety were moderately associated with overall 2-back task performance. These findings suggest that non-clinical anxiety affects the recruitment of cortical resources during working memory, but that anxiety does not impair performance during a 2-back task.

History

Journal

Psychiatry Research - Neuroimaging

Volume

278

Pagination

92-97

Location

Netherlands

ISSN

0925-4927

eISSN

1872-7506

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, Elsevier

Publisher

ELSEVIER IRELAND LTD