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Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

Version 2 2024-06-04, 03:38
Version 1 2018-04-04, 11:47
journal contribution
posted on 2024-06-04, 03:38 authored by Agnes MichalczykAgnes Michalczyk, ED Janus, A Judge, PR Ebeling, JD Best, MJ Ackland, D Asproloupos, James DunbarJames Dunbar, Leigh AcklandLeigh Ackland
Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8–10 and 20 weeks postpartum and in never-pregnant women. Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Conclusion: Histone methylation changes are transient in pregnancy and early postpartum and may represent normal physiological responses to hormones. Different epigenomic profiles in women with type 2 diabetes mellitus may correlate with hormonal responses, leading to high risk pregnancy outcomes.

History

Journal

Epigenomics

Volume

10

Pagination

419-431

Location

England

ISSN

1750-1911

eISSN

1750-192X

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2018, Future Medicine Ltd

Issue

4

Publisher

FUTURE MEDICINE LTD