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Transmissible cancers in an evolutionary context

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journal contribution
posted on 2016-01-01, 00:00 authored by Beata UjvariBeata Ujvari, A T Papenfuss, K Belov
Cancer is an evolutionary and ecological process in which complex interactions between tumour cells and their environment share many similarities with organismal evolution. Tumour cells with highest adaptive potential have a selective advantage over less fit cells. Naturally occurring transmissible cancers provide an ideal model system for investigating the evolutionary arms race between cancer cells and their surrounding micro-environment and macro-environment. However, the evolutionary landscapes in which contagious cancers reside have not been subjected to comprehensive investigation. Here, we provide a multifocal analysis of transmissible tumour progression and discuss the selection forces that shape it. We demonstrate that transmissible
cancers adapt to both their micro-environment and macroenvironment,
and evolutionary theories applied to organisms are also relevant to these unique diseases.

History

Journal

Inside the cell

Volume

1

Issue

1

Pagination

17 - 26

Publisher

Wiley-Blackwell

Location

Chichester, Eng.

eISSN

2375-2920

Language

eng

Publication classification

X Not reportable; C2 Other contribution to refereed journal

Copyright notice

2015, The Authors

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