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Transmission risk of avian influenza virus along poultry supply chains in Guangdong, China
journal contributionposted on 2023-07-17, 02:56 authored by JY Wu, EH Lau, J Yuan, ML Lu, CJ Xie, KB Li, XW Ma, JD Chen, YH Liu, L Cao, MX Li, B Di, YF Liu, JY Lu, TG Li, XC Xiao, DH Wang, ZC Yang, JH Lu
Objectives: Avian influenza viruses (AIVs) poise significant risk to human health and the poultry industry. We evaluated the transmission risk along the poultry supply chain. Methods: During October 2015 and July 2016, four rounds of cross-sectional surveys were performed to characterize AIV spread in farms, transport vehicles, slaughterhouses, wholesale and retail live poultry markets (LPMs). Poultry cloacal and oral swabs, environmental swabs, bioaerosol samples and human sera were collected. Poultry and environmental samples were tested for AIVs by rRT-PCR, further subtyped by next generation sequencing. Previous human H9N2 infections were identified by hemagglutination inhibition and microneutralization tests. Logistic regression was fitted to compare AIV transmission risk in different settings. Results: AIVs was detected in 23.9% (424/1771) of the poultry and environmental samples. AIV detection rates in farms, transport vehicles, wholesale and retail LPMs were 4.5%, 11.1%, 30.3% and 51.2%, respectively. 5.2%, 8.3% and 12.8% of the poultry workers were seropositive in farms, wholesale and retail LPMs, respectively. The regression analysis showed that virus detection and transmission risk to human increased progressively along the poultry supply chain. Conclusions: Strengthening control measures at every level along the poultry supply chain, using a one health approach, is crucial to control AIV circulation.
JournalJournal of Infection
Publication classificationC1.1 Refereed article in a scholarly journal
Avian influenza virusOne healthPoultry supply chainPoultry workerPrevalenceTransmission riskAdolescentAdultAgedAnimalsChinaCloacaCross-Sectional StudiesDisease Transmission, InfectiousEnvironmental MicrobiologyFemaleGenotypeGenotyping TechniquesHumansInfluenza A virusInfluenza in BirdsInfluenza, HumanMaleMiddle AgedMouthPoultryReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRisk AssessmentYoung AdultZoonosesavian influenza viruspoultry supply chainpoultry workerprevalencetransmission riskone health3207 Medical Microbiology32 Biomedical and Clinical Sciences3202 Clinical SciencesPrevention2 Aetiology2.2 Factors relating to the physical environmentInfection3202 Clinical sciencesClinical Sciences not elsewhere classified