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Triggering nanoparticle surface ligand rearrangement via external stimuli: light-based actuation of biointerfaces

Version 2 2024-06-06, 08:06
Version 1 2015-08-31, 11:55
journal contribution
posted on 2024-06-06, 08:06 authored by Z Tang, CK Lim, JP Palafox-Hernandez, KL Drew, Y Li, MT Swihart, PN Prasad, Tiffany WalshTiffany Walsh, MR Knecht
Bio-molecular non-covalent interactions provide a powerful platform for material-specific self-organization in aqueous media. Here, we introduce a strategy that integrates a synthetic optically-responsive motif with a materials-binding peptide to enable remote actuation. Specifically, we linked a photoswitchable azobenzene moiety to either terminus of a Au-binding peptide. We employed these hybrid molecules as capping agents for synthesis of Au nanoparticles. Integrated experiments and molecular simulations showed that the hybrid molecules maintained both of their functions, i.e. binding to Au and optically-triggered reconfiguration. The azobenzene unit was optically switched reversibly between trans and cis states while adsorbed on the particle surface. Upon switching, the conformation of the peptide component of the molecule also changed. This highlights the interplay between the surface adsorption and conformational switching that will be pivotal to the creation of actuatable nanoparticle bio-interfaces, and paves the way toward multifunctional peptide hybrids that can produce stimuli responsive nanoassemblies.

History

Journal

Nanoscale

Volume

7

Pagination

13638-13645

Location

Cambridge, Eng.

ISSN

2040-3364

eISSN

2040-3372

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2015, Royal Society of Chemistry

Issue

32

Publisher

Royal Society of Chemistry