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Tunable biodegradable silk-based memory foams with controlled release of antibiotics

journal contribution
posted on 01.01.2020, 00:00 authored by L Chambre, R N Parker, Ben AllardyceBen Allardyce, F Valente, Rangam RajkhowaRangam Rajkhowa, R J Dilley, Xungai WangXungai Wang, D L Kaplan
Sustained, local delivery of the antibiotic ciprofloxacin under different formats from porous silk protein-based memory foam systems was studied. Similarly, protease XIV was incorporated during processing to provide control of the degradation kinetics of the silk materials. In vitro antibiotic release studies combined with degradation assessments were utilized to assess the mechanisms and kinetics of release from the silk materials. The sequestered protease XIV affected the degradation profiles of the silk foams yet did not impact the release kinetics of the ciprofloxacin, which was controlled by solubility and diffusion of the drug. The ability to tune the release of ciprofloxacin between 1 and 200 days, combined with the option to modulate the degradation rate up to 80% in 2 weeks via incorporation of a protease, suggests utility for drug release devices. Further, we anticipate that this approach could also be extended to other medical implant needs and other drugs.

History

Journal

ACS applied bio materials

Volume

3

Issue

4

Pagination

2466 - 2472

Publisher

American Chemical Society

Location

Washington, D.C.

ISSN

2576-6422

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal