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Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly

journal contribution
posted on 01.01.2013, 00:00 authored by A Rodriguez, C Parish, D Nisbet, Richard WilliamsRichard Williams
Nanofibrous materials yielded by the self-assembly of peptides are rich in potential; particularly for the formation of scaffolds that mimic the landscape of the host environment of the cell. Here, we report a novel methodology to direct the formation of supramolecular structures presenting desirable amino acid sequences by the self-assembly of minimalist peptides which cannot otherwise yield the desired scaffold structures under biologically relevant conditions. Through the rational modification of the pK?, we were able to optimise ordered charge neutralised assembly towards in vivo conditions.

History

Journal

Soft matter

Volume

9

Issue

15

Pagination

3915 - 3919

Publisher

Royal Society of Chemistry

Location

Cambridge, England

ISSN

1744-683X

eISSN

1744-6848

Language

eng

Publication classification

C1 Refereed article in a scholarly journal