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Turning natural adaptations to oncogenic factors into an ally in the war against cancer

journal contribution
posted on 01.07.2018, 00:00 authored by M Vittecoq, M Giraudeau, T Sepp, D J Marcogliese, Marcel KlaassenMarcel Klaassen, F Renaud, Beata UjvariBeata Ujvari, F Thomas
Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression. Building on a substantial knowledge base from the literature, we here present and discuss this progressive and promising research direction, advocating closer collaboration between the fields of medicine, ecology, and evolution in the war against cancer.

History

Journal

Evolutionary applications

Volume

11

Issue

6

Pagination

836 - 844

Publisher

John Wiley & Sons

Location

Chichester, Eng.

ISSN

1752-4563

eISSN

1752-4571

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2018, The Authors