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Two enteric coated microspheres in cystic fibrosis

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Version 2 2024-06-13, 11:16
Version 1 2019-07-16, 14:12
journal contribution
posted on 2024-06-13, 11:16 authored by J Williams, A MacDonald, PH Weller, J Fields, H Pandov
In a randomised single blind crossover study in children with cystic fibrosis and pancreatic insufficiency, two enteric coated microsphere preparations of pancreatin were compared on a capsule for capsule basis, by measuring the coefficient of fat absorption, nitrogen excretion, weight change, and symptom scores after four weeks' treatment with each preparation. Thirty nine subjects were randomly allocated to receive Pancrease followed by Creon or vice versa. Each individual subject received the same number of capsules per day in each study period. Data from 27 children (Pancrease/Creon, n = 13 and Creon/Pancrease, n = 14) were suitable for analysis. Results showed no significant differences between the two preparations in any variable studied. We conclude that there is no significant difference between Pancrease and Creon when compared on a capsule for capsule basis.

History

Journal

Archives of disease in childhood

Volume

65

Pagination

594-597

Location

London, Eng.

Open access

  • Yes

ISSN

0003-9888

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1990, BMJ Publishing Group Ltd and the Royal College of Paediatrics and Child Health

Issue

6

Publisher

BMJ Publishing Group

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