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Type-II diabetes and pancreatic cancer: A meta-analysis of 36 studies

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journal contribution
posted on 06.06.2005, 00:00 authored by Rachel HuxleyRachel Huxley, A Ansary-Moghaddam, A Berrington De González, F Barzi, M Woodward
Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes is widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association is unclear. We conducted a meta-analysis to examine this association. A computer-based literature search from 1966 to 2005 yielded 17 case-control and 19 cohort or nested case-control studies with information on 9220 individuals with pancreatic cancer. The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study. The combined summary odds ratio was 1.82 (95% confidence interval (95% CI) 1.66-1.89), with evidence of heterogeneity across the studies (P = 0.002 for case-control and P = 0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported before 2000. Individuals in whom diabetes had only recently been diagnosed (<4 years) had a 50% greater risk of the malignancy compared with individuals who had diabetes for ≥5 years (OR 2.1 vs 1.5; P = 0.005), These results support a modest causal association between type-II diabetes and pancreatic cancer.

History

Journal

British Journal of Cancer

Volume

92

Issue

11

Pagination

2076 - 2083

Publisher

Nature Publishing Group

Location

London, Eng.

ISSN

0007-0920

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, Cancer Research UK