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Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

journal contribution
posted on 2011-08-07, 00:00 authored by Hong Zhou, Jing Liu, Jing-Juan Xu, Hong-Yuan Chen
We report here an ultrasensitive DNA detection approach which combines Au NPs enhanced electrochemiluminescence (ECL) of the CdS nanocrystal (NC) film with isothermal circular amplification reaction of polymerase and nicking endonuclease (NEase). By the double-signal amplification, this approach could sensitively respond down to 5 aM DNA.

History

Journal

Chemical communications

Volume

47

Pagination

8358-8360

Location

Cambridge, Eng.

ISSN

1359-7345

eISSN

1364-548X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2011, Royal Society of Chemistry

Issue

29

Publisher

Royal Society of Chemistry

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