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Uncovering the transmission dynamics of Plasmodium vivax using population genetics

Version 3 2024-06-14, 07:32
Version 2 2024-06-05, 04:00
Version 1 2020-05-11, 12:28
journal contribution
posted on 2024-06-14, 07:32 authored by Alyssa BarryAlyssa Barry, A Waltmann, C Koepfli, C Barnadas, I Mueller
© W. S. Maney & Son Ltd 2015. Population genetic analysis ofmalaria parasites has the power to reveal key insights into malaria epidemiology and transmission dynamics with the potential to deliver tools to support control and elimination efforts. Analyses of parasite genetic diversity have suggested that Plasmodium vivax populations are more genetically diverse and less structured than those ofPlasmodiumfalciparumindicating thatP. vivaxmay be amore ancientparasite ofhumans and/or less susceptibletopopulationbottlenecks, aswell asmoreefficient atdisseminatingitsgenes. These population genetic insights into P. vivax transmission dynamics provide an explanation for its relative resilience to control efforts. Here, we describe current knowledge on P. vivax population genetic structure, its relevance to understanding transmission patterns and relapse and how this information can inform malaria control and elimination programmes.

History

Journal

Pathogens and Global Health

Volume

109

Pagination

142-152

Location

London, Eng.

ISSN

2047-7724

eISSN

2047-7732

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

3

Publisher

Taylor & Francis

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