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Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis

journal contribution
posted on 2023-12-19, 03:46 authored by Samuel C Wassmer, Tania De Koning-WardTania De Koning-Ward, Georges ER Grau, Saparna Pai
Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium falciparum parasites; it is characterized by the sequestration of infected red blood cells within the cerebral microvasculature. New findings, combined with a better understanding of the central nervous system (CNS) barriers, have provided greater insight into the players and events involved in CM, including site-specific T cell responses in the human brain. Here, we review the updated roles of innate and adaptive immune responses in CM, with a focus on the role of the perivascular macrophage-endothelium unit in antigen presentation, in the vascular and perivascular compartments. We suggest that these events may be pivotal in the development of CM.

History

Journal

Trends in Parasitology

Pagination

S1471-4922(23)00285-4-

Location

England

ISSN

1471-4922

eISSN

1471-5007

Language

en

Publisher

Elsevier BV