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Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection
journal contribution
posted on 2023-02-06, 23:08 authored by AJ McAuley, P Jansen van Vuren, MUR Mohammed, Faheem, S Goldie, S Riddell, NJ Gödde, IK Styles, MP Bruce, S Chahal, S Keating, KR Blasdell, M Tachedjian, CM O’Brien, NB Singanallur, JN Viana, AV Vashi, CM Kirkpatrick, CA MacRaild, RM Shah, E Vincan, Eugene AthanEugene Athan, DJ Creek, NL Trevaskis, S Murugesan, A Kumar, SS VasanThe repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given circa 7817 licenced compounds available from Compounds Australia that can be screened, this paper demonstrates the utility of commercially available ex vivo/3D airway and alveolar tissue models. These models are a closer representation of in vivo studies than in vitro models, but retain the benefits of rapid in vitro screening for drug efficacy. We demonstrate that several existing drugs appear to show anti-SARS-CoV-2 activity against both SARS-CoV-2 Delta and Omicron Variants of Concern in the airway model. In particular, fluvoxamine, as well as aprepitant, everolimus, and sirolimus, has virus reduction efficacy comparable to the current standard of care (remdesivir, molnupiravir, nirmatrelvir). Whilst these results are encouraging, further testing and efficacy studies are required before clinical use can be considered.
History
Journal
VirusesVolume
14Article number
2417Pagination
1-18Location
Basel, SwitzerlandPublisher DOI
ISSN
1999-4915eISSN
1999-4915Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
11Publisher
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Keywords
3D tissue modelsCOVID-19CoviRxdrug repurposingINHIBITIONLife Sciences & BiomedicineorgScience & TechnologytherapeuticsVirologyCoviRx.orgHumansSARS-CoV-2PandemicsLungAntiviral AgentsCOVID-19 Drug TreatmentPreventionPneumoniaInfectious Diseases5.1 Pharmaceuticals5 Development of treatments and therapeutic interventions3 Good Health and Well BeingMicrobiology
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