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Use of theta-burst stimulation in changing excitability of motor cortex: a systematic review and meta-analysis
journal contribution
posted on 2016-04-01, 00:00 authored by S W Chung, Aron HillAron Hill, N C Rogasch, K E Hoy, P B FitzgeraldNoninvasive brain stimulation has been demonstrated to modulate cortical activity in humans. In particular, theta burst stimulation (TBS) has gained notable attention due to its ability to induce lasting physiological changes after short stimulation durations. The present study aimed to provide a comprehensive meta-analytic review of the efficacy of two TBS paradigms; intermittent (iTBS) and continuous (cTBS), on corticospinal excitability in healthy individuals. Literature searches yielded a total of 87 studies adhering to the inclusion criteria. iTBS yielded moderately large MEP increases lasting up to 30 min with a pooled SMD of 0.71 (p < 0.00001). cTBS produced a reduction in MEP amplitudes lasting up to 60 min, with the largest effect size seen at 5 min post stimulation (SMD = -0.9, P < 0.00001). The collected studies were of heterogeneous nature, and a series of tests conducted indicated a degree of publication bias. No significant change in SICI and ICF was observed, with exception to decrease in SICI with cTBS at the early time point (SMD = 0.42, P = 0.00036). The results also highlight several factors contributing to TBS efficacy, including the number of pulses, frequency of stimulation and BDNF polymorphisms. Further research investigating optimal TBS stimulation parameters, particularly for iTBS, is needed in order for these paradigms to be successfully translated into clinical settings.
History
Journal
Neuroscience and biobehavioral reviewsVolume
63Pagination
43 - 64Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyTheta-burst stimulation (TBS)Transcranial magnetic stimulation (TMS)Motor cortexMotor-evoked potentials (MEPs)Cortical excitabilityNeuromodulationTRANSCRANIAL MAGNETIC STIMULATIONNONINVASIVE BRAIN-STIMULATIONPAIRED ASSOCIATIVE STIMULATIONBDNF VAL66MET POLYMORPHISMLONG-TERM PLASTICITYLTP-LIKE PLASTICITYCORTICAL PLASTICITYCORTICOSPINAL EXCITABILITYPUBLICATION BIASINTERINDIVIDUAL VARIABILITY