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Using transcranial magnetic stimulation to quantify electrophysiological changes following concussive brain injury: a systematic review
journal contribution
posted on 2015-04-01, 00:00 authored by Brendan Major, Mark RogersMark Rogers, Alan PearceMild traumatic brain injury (mTBI) and sports concussion are a growing public health concern, with increasing demands for more rigorous methods to quantify changes in the brain post-injury. Electrophysiology, and in particular, transcranial magnetic stimulation (TMS), have been demonstrated to provide prognostic value in a range of neurological conditions; however, no review has quantified the efficacy of TMS in mTBI/concussion. In the present study, we present a systematic review and critical evaluation of the scientific literature from 1990 to 2014 that has used TMS to investigate corticomotor excitability responses at short-term (< 12 months), medium-term (1-5 years), and long-term (> 5 years) post-mTBI/concussion. Thirteen studies met the selection criteria, with six studies presenting short-term changes, five studies presenting medium-term changes, and two studies presenting long-term changes. Irrespective of time post-concussion, change in intracortical inhibition was the most reported observation. Other findings included increased stimulation threshold, and slowed neurological conduction time. Although currently limited, the data suggest that TMS has prognostic value in detecting neurophysiological changes post-mTBI/concussion.
History
Journal
Clinical and experimental pharmacology and physiologyVolume
42Issue
4Pagination
394 - 405Publisher
Wiley-Blackwell Publishing AsiaLocation
Richmond, Vic.Publisher DOI
ISSN
1440-1681Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, WileyUsage metrics
Keywords
concussionevoked potentialmild traumatic brain injurysystematic reviewtranscranial magnetic stimulationScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyPhysiologySPORT-RELATED CONCUSSIONHUMAN MOTOR CORTEXCHRONIC TRAUMATIC ENCEPHALOPATHYIMPAIRED CORTICAL INHIBITIONSILENT PERIODHEAD-INJURYLONG-TERMINTRACORTICAL INHIBITIONFOOTBALL CODESEXCITABILITYPhysiology
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