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Vaccination with Aleutian mink disease parvovirus (AMDV) capsid proteins enhances disease, while vaccination with the major non-structural AMDV protein causes partial protection from disease

journal contribution
posted on 1998-07-01, 00:00 authored by B Aasted, Soren AlexandersenSoren Alexandersen, J Christensen
Vaccination studies were performed with partially purified recombinant AMDV VP1/2 capsids as well as with the major AMDV non-structural protein (NS1). All vaccine constructs induced an antibody response, but did not prevent infection upon challenge with AMDV. The severity of Aleutian disease (AD) was judged by the serum gammaglobulin level, the quantity of peripheral blood CD8 lymphocytes, antibody titers to VP1/2 and NS1 proteins and mink death rates. The VP1/2 vaccine constructs enhanced the disease process with drastic death rates for the vaccinated mink. On the contrary, the NS1 vaccine constructs resulted in milder AD than seen in the non-vaccinated mink.

History

Journal

Vaccine

Volume

16

Issue

11-12

Pagination

1158 - 1165

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0264-410X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1998, Elsevier