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Validation and advantages of FAWSETS perfusion measurements in skeletal muscle
journal contribution
posted on 2005-06-01, 00:00 authored by K I Marro, O M Hyyti, Michelle KeskeMichelle Keske, M J KushmerickThis work discusses the strengths, limitations and validity of a novel arterial spin labeling technique when used specifically to measure perfusion in limb skeletal muscle. The technique, flow-driven arterial water stimulation with elimination of tissue signal (FAWSETS), offers several advantages over existing arterial spin labeling techniques. The primary goal of this study was to determine the perfusion signal response to changes in net hind limb flow that were independently verifiable. The range of perfusate flow was relevant to skeletal muscle during mild to moderate exercise. Localized, single voxel measurements were acquired from a 5 mm-thick slice in the isolated perfused rat hind limb at variable net flow rates. The results show that the perfusion signal is linearly proportional to net hind limb flow with a correlation coefficient of 0.974 (p = 0.0013). FAWSETS is especially well suited for studies of skeletal muscle perfusion, where it eliminates the need to compensate for magnetization transfer and arterial transit time effects. A conceptual discussion of the basic principles underlying these advantages is presented.
History
Journal
NMR in biomedicineVolume
18Issue
4Pagination
226 - 234Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
0952-3480Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2005, John Wiley & SonsUsage metrics
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AlgorithmsAnimalsArteriesBlood Flow VelocityDiffusion Magnetic Resonance ImagingImage Interpretation, Computer-AssistedMuscle, SkeletalRatsReproducibility of ResultsRheologySensitivity and SpecificityWaterarterial spin labelingperfusionskeletal musclerat hind limbScience & TechnologyLife Sciences & BiomedicineTechnologyBiophysicsRadiology, Nuclear Medicine & Medical ImagingSpectroscopyCEREBRAL-BLOOD-FLOWMAGNETIZATION-TRANSFER CONTRASTARTERIAL WATERMYOCARDIAL-PERFUSIONTREADMILL EXERCISEIMAGING TECHNIQUESBRAIN PERFUSIONRAT HINDQUARTERFAIR TECHNIQUETRANSIT-TIME
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