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Validation and characterization of a novel peptide that binds monomeric and aggregated β-amyloid and inhibits the formation of neurotoxic oligomers

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posted on 2016-01-08, 00:00 authored by R K Barr, G Verdile, L K Wijaya, M Morici, K Taddei, Veer GuptaVeer Gupta, S Pedrini, L Jin, J A Nicolazzo, E Knock, P E Fraser, R N Martins
Validation and characterization of a novel peptide that binds monomeric and aggregated β-amyloid and inhibits the formation of neurotoxic oligomers

History

Journal

Journal of Biological Chemistry

Volume

291

Issue

2

Pagination

547 - 559

Publisher

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Location

United States

Publisher DOI

Link to full text

ISSN

0021-9258

eISSN

1083-351X

Language

English

Author URL

Publication classification

C1 Refereed article in a scholarly journal

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    Keywords

    Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyIMAGE PHAGE DISPLAYALZHEIMERS-DISEASEA-BETAMOUSE MODELTRANSGENIC MICEIN-VIVONATURAL OLIGOMERSFIBRIL FORMATIONPROTEIN BINDSBRAINAlzheimer diseaseamyloid-β (AB)imagingneurodegenerationpeptides

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