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Variabilin and related compounds from a sponge of the genus sarcotragus

Version 2 2024-06-03, 13:00
Version 1 2017-07-26, 12:52
journal contribution
posted on 2024-06-03, 13:00 authored by Colin BarrowColin Barrow, JW Blunt, MHG Munro, NB Perry
The bioactivity-directed analysis of the extract from a sponge of the genus Sarcotragus led to the isolation of a series of bioactive sesterterpenes, of which variabilin [1a] was the major component. The sesterterpenes 2a, 3, and 4a, along with the related C 21 furanoterpene [5], were present in lesser amounts. The unequivocal assignment of the stereochemistry of the 20, 21 double bond in variabilin as 20Z was achieved through examination of the 22-O-methyl derivative 1b of variabilin and the isolation of the variabilin isomer 2a with the 20E configuration.

History

Journal

Journal of natural products

Volume

51

Pagination

275-281

Location

Washington, D.C.

ISSN

0163-3864

eISSN

1520-6025

Language

eng

Publication classification

CN.1 Other journal article

Copyright notice

[1988, ACS Publications]

Issue

2

Publisher

ACS Publications

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