stambas-visualizingthe-2019.pdf (3.67 MB)
Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo
journal contribution
posted on 2019-12-10, 00:00 authored by S A Stifter, N Bhattacharyya, A J Sawyer, T A Cootes, John StambasJohn Stambas, S E Doyle, L Feigenbaum, W E Paul, W J Britton, A Sher, C G Feng© 2019 The Author(s) Stifter et al. generated an Irgm1 reporter mouse sensitive to induction by all three types of IFNs. They show that cellular responses to IFNs are highly heterogenous in vivo. Furthermore, different types of IFNs act in a cell-type-dependent manner to convey synergistic, antagonistic, or non-redundant signaling during influenza infection.
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Journal
Cell ReportsVolume
29Pagination
3539 - 3550Publisher
Cell PressLocation
Cambridge, Ma.Publisher DOI
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2211-1247Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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