daly-vitamindbones-2017.pdf (198.62 kB)
Download fileVitamin D, bones and muscle: myth versus reality
journal contribution
posted on 2017-03-01, 00:00 authored by G Duque, Robin DalyRobin Daly, K Sanders, D P KielOBJECTIVES: Evidence regarding the efficacy and dosing of vitamin D on fall and fracture prevention, with or without calcium, is characterised by uncertainty. METHODS: A panel of experts was organised at the First Australasian Conference on Sarcopenia and Frailty in Melbourne, Australia, in November 2016 to provide an interpretation of the current evidence and to give their opinions regarding the supplementation of vitamin D in three hypothetical cases. RESULTS AND CONCLUSION: The authors conclude that (i) target serum 25(OH)D concentration should be 50 to 60 nmol/L year round, with a conservative upper limit <100 nmol/L; (ii) change in serum concentrations at any given dose is highly variable among individuals; (iii) dosing interval may need to be <2 months to have a continuous benefit; (iv) a loading dose can raise levels to target quickly, but there is no evidence yet that this has any positive effect on falls or fracture outcomes; and (v) a maintenance dose of 1000 IU/day, or given as an equivalent dose weekly or monthly, is sufficient for most individuals.
History
Journal
Australasian journal on ageingVolume
36Issue
Suppl 1Pagination
8 - 13Publisher
Wiley-BlackwellLocation
Chichester, Eng.Publisher DOI
Link to full text
eISSN
1741-6612Language
engNotes
Special Issue: First Australia and New Zealand Conference on Sarcopenia and Frailty Research, 11–12 November 2016, Pullman Melbourne AlbertPark, VictoriaPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, AJAUsage metrics
Categories
Keywords
fallsfracturesosteoporosissarcopeniavitamin DAccidental FallsAge FactorsAgedAged, 80 and overAgingAnimalsBiomarkersBone RemodelingDietary SupplementsEvidence-Based MedicineFrail ElderlyHumansMuscle StrengthOsteoporotic FracturesRisk FactorsVitamin D DeficiencyScience & TechnologyLife Sciences & BiomedicineGeriatrics & GerontologyGerontologyD SUPPLEMENTATIONCALCIUM INTAKEOLDER-ADULTSD DEFICIENCYMETAANALYSISPREVENTIONWOMENRISK