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Vitamin D during pregnancy and offspring body composition: a prospective cohort study
journal contribution
posted on 2018-08-01, 00:00 authored by Natalie HydeNatalie Hyde, Sharon Brennan-OlsenSharon Brennan-Olsen, J D Wark, Sarah HoskingSarah Hosking, K L Holloway-Kew, Julie PascoJulie PascoBACKGROUND: Evidence regarding the association between gestational vitamin D status and offspring body composition during childhood is inconsistent. Therefore, we aimed to determine the association between maternal vitamin D and offspring lean and fat mass in the Vitamin D in Pregnancy birth cohort. METHODS: Subjects were mother-child pairs recruited from the Australian-based Vitamin D in Pregnancy cohort study. Mothers were recruited before 16 weeks' gestation and provided a blood sample at both recruitment and at 28-32 weeks' gestation. Serum vitamin D [25(OH)D] was measured by radioimmunoassay (Tyne and Wear, UK). Offspring lean and fat mass were quantified by using dual-energy X-ray absorptiometry (GE Lunar Prodigy, Madison, WI, USA) at 11 years of age. RESULTS: Median maternal 25(OH)D levels were 55.9 (42.2-73.3) and 56.1 (43.6-73.9) at recruitment and 28-32 weeks' gestation, respectively. Maternal smoking was identified as an effect modifier in the association between maternal vitamin D status at recruitment and offspring body composition. In smokers, but not non-smokers, serum 25(OH)D status at recruitment was negatively associated with offspring fat mass percentage and positively associated with lean mass (both p < 0.05). There was no association with 25(OH)D status at 28-32 weeks' gestation. CONCLUSIONS: Maternal vitamin D status in early pregnancy, in smokers, is associated with offspring body composition. These important findings warrant confirmation in larger studies and trials.
History
Journal
Pediatric obesityVolume
13Issue
8Season
Special IssuePagination
514 - 521Publisher
WileyLocation
chichester, EnglandPublisher DOI
eISSN
2047-6310Language
engNotes
Special Issue: Maternal‐Infant Nutritional Factors and Risk for Early Obesity DevelopmentPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, World Obesity FederationUsage metrics
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