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Vitamin D during pregnancy and offspring body composition: a prospective cohort study

journal contribution
posted on 01.08.2018, 00:00 authored by Natalie HydeNatalie Hyde, Sharon Brennan-OlsenSharon Brennan-Olsen, J D Wark, Sarah HoskingSarah Hosking, K L Holloway-Kew, Julie PascoJulie Pasco
BACKGROUND: Evidence regarding the association between gestational vitamin D status and offspring body composition during childhood is inconsistent. Therefore, we aimed to determine the association between maternal vitamin D and offspring lean and fat mass in the Vitamin D in Pregnancy birth cohort. METHODS: Subjects were mother-child pairs recruited from the Australian-based Vitamin D in Pregnancy cohort study. Mothers were recruited before 16 weeks' gestation and provided a blood sample at both recruitment and at 28-32 weeks' gestation. Serum vitamin D [25(OH)D] was measured by radioimmunoassay (Tyne and Wear, UK). Offspring lean and fat mass were quantified by using dual-energy X-ray absorptiometry (GE Lunar Prodigy, Madison, WI, USA) at 11 years of age. RESULTS: Median maternal 25(OH)D levels were 55.9 (42.2-73.3) and 56.1 (43.6-73.9) at recruitment and 28-32 weeks' gestation, respectively. Maternal smoking was identified as an effect modifier in the association between maternal vitamin D status at recruitment and offspring body composition. In smokers, but not non-smokers, serum 25(OH)D status at recruitment was negatively associated with offspring fat mass percentage and positively associated with lean mass (both p < 0.05). There was no association with 25(OH)D status at 28-32 weeks' gestation. CONCLUSIONS: Maternal vitamin D status in early pregnancy, in smokers, is associated with offspring body composition. These important findings warrant confirmation in larger studies and trials.

History

Journal

Pediatric obesity

Volume

13

Issue

8

Season

Special Issue

Pagination

514 - 521

Publisher

Wiley

Location

chichester, England

eISSN

2047-6310

Language

eng

Notes

Special Issue: Maternal‐Infant Nutritional Factors and Risk for Early Obesity Development

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, World Obesity Federation