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Volume dependence of airway and tissue impedances in mice

Version 2 2024-06-06, 12:44
Version 1 2022-03-30, 15:44
journal contribution
posted on 2024-06-06, 12:44 authored by PD Sly, RA Collins, C Thamrin, DJ Turner, Z Hantos
We measured respiratory input impedance (1–25 Hz) in mice and obtained parameters for airway and tissue mechanics by model fitting. Lung volume was varied by inflating to airway opening pressure (Pao) between 0 and 20 cmH2O. The expected pattern of changes in respiratory mechanics with increasing lung volume was seen: a progressive fall in airway resistance and increases in the coefficients of tissue damping and elastance. A surprising pattern was seen in hysteresivity (η), with a plateau at low lung volumes (Pao < 10 cmH2O), a sharp fall occurring between 10 and 15 cmH2O, and η approaching a second (lower) plateau at higher lung volumes. Studies designed to elucidate the mechanism(s) behind this behavior revealed that this was not due to chest wall properties, differences in volume history at low lung volume, time dependence of volume recruitment, or surface-acting forces. Our data are consistent with the notion that at low lung volumes the mechanics of the tissue matrix determine η, whereas at high lung volumes the properties of individual fibers (collagen) become more important.

History

Journal

Journal of Applied Physiology

Volume

94

Pagination

1460-1466

Location

United States

ISSN

8750-7587

eISSN

1522-1601

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

4

Publisher

AMER PHYSIOLOGICAL SOC

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