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Volumetric abnormalities predating the onset of schizophrenia and affective psychoses: An MRI study in subjects at ultrahigh risk of psychosis
journal contribution
posted on 2022-11-30, 02:50 authored by P Dazzan, B Soulsby, A Mechelli, S J Wood, D Velakoulis, L J Phillips, Alison YungAlison Yung, X Chitnis, A Lin, R M Murray, P D McGorry, P K McGuire, C PantelisIt remains unclear whether brain structural abnormalities observed before the onset of psychosis are specific to schizophrenia or are common to all psychotic disorders. This study aimed to measure regional gray matter volume prior to the onset of schizophreniform and of affective psychoses. We investigated 102 subjects at ultrahigh risk (UHR) of developing psychosis recruited from the Personal Assessment and Crisis Evaluation Clinic in Melbourne, Australia. Twenty-eight of these subjects developed psychosis subsequent to scanning: 19 schizophrenia, 7 affective psychoses, and 2 other psychoses. We examined regional gray matter volume using 1.5 mm thick, coronal, 1.5 Tesla magnetic resonance imaging and voxel-based morphometry methods of image analysis. Subjects were scanned at presentation and were followed up clinically for a minimum of 12 months, to detect later transition to psychosis. We found that both groups of subjects who subsequently developed psychosis (schizophrenia and affective psychosis) showed reductions in the frontal cortex relative to UHR subjects who did not develop psychosis. The subgroup that subsequently developed schizophrenia also showed smaller volumes in the parietal cortex and, at trend level, in the temporal cortex, whereas those who developed an affective psychosis had significantly smaller subgenual cingulate volumes. These preliminary findings suggest that volumetric abnormalities in UHR individuals developing schizophrenia vs affective psychoses comprise a combination of features that predate both disorders and others that may be specific to the nature of the subsequent disorder. © 2012 The Author.
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Journal
Schizophrenia BulletinVolume
38Pagination
1083 - 1091Publisher DOI
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ISSN
0586-7614eISSN
1745-1701Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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Science & TechnologyLife Sciences & BiomedicinePsychiatryultrahigh riskschizophreniaaffective psychosisMRIbrain structurepsychosisVOXEL-BASED MORPHOMETRY1ST-EPISODE AFFECTIVE PSYCHOSISANTERIOR CINGULATE CORTEXGRAY-MATTER VOLUMEADULT HUMAN BRAINSBIPOLAR DISORDERCOMPREHENSIVE ASSESSMENTAMYGDALA VOLUMESLONGITUDINAL MRIWORKING-MEMORY
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