In a world where racism persists undiminished (if not intensified) in a multitude of configurations, there is a pressing need to consider the state of anti-racist theory and practice. Drawing on the multidisciplinary contributions to this special issue alongside a panoramic snapshot of current scholarship, this article wrestles with several matters central to the ongoing development of anti-racism. Junctures with social justice, equality, recognition, tolerance, indifference, and acknowledgement are explored along with the varieties, and co-constitutions, of racism and anti-racism. Post-racial potentialities and the double-bind of anti-racism amidst the twin liberal desires of sameness and difference are examined alongside the nascent growth of alter-racism via concepts such as embodiment, viscerality, humour, affective ambiences, and everyday race labour. It is hoped that this article will foster ongoing reflection, discussion, and, most importantly, action aimed at defying racism across the globe.