caeyenberghs-wholebrain-2015.pdf (733.72 kB)
Whole-brain structural topology in adult attention-deficit/hyperactivity disorder: Preserved global - Disturbed local network organization
journal contribution
posted on 2015-01-01, 00:00 authored by J Sidlauskaite, Karen CaeyenberghsKaren Caeyenberghs, E Sonuga-Barke, H Roeyers, J R Wiersema© 2015 The Authors. Published by Elsevier Inc. Prior studies demonstrate altered organization of functional brain networks in attention-deficit/hyperactivity disorder (ADHD). However, the structural underpinnings of these functional disturbances are poorly understood. In the current study, we applied a graph-theoretic approach to whole-brain diffusion magnetic resonance imaging data to investigate the organization of structural brain networks in adults with ADHD and unaffected controls using deterministic fiber tractography. Groups did not differ in terms of global network metrics - small-worldness, global efficiency and clustering coefficient. However, there were widespread ADHD-related effects at the nodal level in relation to local efficiency and clustering. The affected nodes included superior occipital, supramarginal, superior temporal, inferior parietal, angular and inferior frontal gyri, as well as putamen, thalamus and posterior cerebellum. Lower local efficiency of left superior temporal and supramarginal gyri was associated with higher ADHD symptom scores. Also greater local clustering of right putamen and lower local clustering of left supramarginal gyrus correlated with ADHD symptom severity. Overall, the findings indicate preserved global but altered local network organization in adult ADHD implicating regions underpinning putative ADHD-related neuropsychological deficits.
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NeuroImage: ClinicalVolume
9Pagination
506 - 512Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
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2213-1582Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Attention deficit\/hyperactivity disorderDiffusion MRIDeterministic tractographyGraph theoryScience & TechnologyLife Sciences & BiomedicineNeuroimagingNeurosciences & NeurologyGRAPH-THEORETICAL ANALYSISDEFICIT HYPERACTIVITY DISORDERDEFAULT-MODE NETWORK33-YEAR FOLLOW-UPSMALL-WORLDFIBER TRACTOGRAPHYCORTICAL NETWORKSNAIVE BOYSCONNECTIVITYSCALE
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