barry-wholegenomeanalysisof-2021.pdf (1000.57 kB)
Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria
journal contribution
posted on 2021-05-25, 00:00 authored by Z Shah, M T Naung, K A Moser, M Adams, A G Buchwald, A Dwivedi, A Ouattara, K B Seydel, D P Mathanga, Alyssa BarryAlyssa Barry, D Serre, M K Laufer, J C Silva, S Takala-HarrisonIndividuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.
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Journal
PLoS geneticsVolume
17Issue
5Article number
e1009576Pagination
1 - 20Publisher
Public Library of ScienceLocation
San Francisco, Calif.Publisher DOI
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ISSN
1553-7390eISSN
1553-7404Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Keywords
Genetics & HeredityLife Sciences & BiomedicineScience & TechnologyImmunityParasitic diseasesMalariaCloningGenomicsVaccinesImmune responseinfectious disease immunologyNATURALLY ACQUIRED ANTIBODIESMEROZOITE ANTIGENSPREDICT PROTECTIONMULTIGENE FAMILYPROTEINRESPONSESINFECTIONSEVOLUTIONMEMBRANECHILDRENGenetics
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