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Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

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posted on 2021-05-25, 00:00 authored by Z Shah, M T Naung, K A Moser, M Adams, A G Buchwald, A Dwivedi, A Ouattara, K B Seydel, D P Mathanga, Alyssa BarryAlyssa Barry, D Serre, M K Laufer, J C Silva, S Takala-Harrison
Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.

History

Journal

PLoS genetics

Volume

17

Issue

5

Article number

e1009576

Pagination

1 - 20

Publisher

Public Library of Science

Location

San Francisco, Calif.

ISSN

1553-7390

eISSN

1553-7404

Language

English

Publication classification

C1 Refereed article in a scholarly journal