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Wnt/β-catenin pathway proteins in end-stage renal disease

Version 2 2024-06-05, 05:06
Version 1 2023-10-23, 02:41
journal contribution
posted on 2024-06-05, 05:06 authored by HK Al-Hakeim, HN Asad, M Maes
Aim: To delineate the association of end-stage renal disease (ESRD) and Wnt-proteins including the agonist R-spondin-1, the transducer β-catenin and the antagonists DKK1 and sclerostin. Materials & methods: Serum Wnt-pathway proteins levels were measured by ELISA in 60 ESRD patients and 30 normal controls. Results: DKK1 and sclerostin were significantly higher in ESRD than in controls, and β-catenin and the catenin + R-spondin-1/DKK1 + sclerostin ratio, reflecting the ratio of agonist and transducer on antagonists (AT/ANTA), were significantly lower in ESRD. Estimated glomerular filtration rate was significantly associated with DKK1 and sclerostin (inversely), β-catenin (positively) and the AT/ANTA ratio (r = 0.468, p < 0.001). Conclusion: Wnt/β-catenin pathway proteins show significant alterations in ESRD, indicating significantly increased levels of antagonists.

History

Journal

Biomarkers in Medicine

Volume

15

Pagination

1423-1434

Location

London, Eng.

ISSN

1752-0363

eISSN

1752-0371

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

15

Publisher

Future Medicine