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YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

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journal contribution
posted on 2015-01-01, 00:00 authored by S M Cheng, Y C Chang, C Y Liu, J Y Lee, H H Chan, C W Kuo, K Y Lin, S L Tsai, S H Chen, C F Li, E Leung, Jagat Kanwar, C C Huang, J Y Chang, C H Cheung
The aim of this study was to determine the potency and molecular mechanism of action of YM155, a first-in-class survivin inhibitor that is currently under phase I/II clinical investigations, in various drug-resistant breast cancers including the oestrogen receptor positive (ER(+) ) tamoxifen-resistant breast cancer and the caspase-3-deficient breast cancer.

History

Journal

British journal of pharmacology

Volume

172

Issue

1

Pagination

214 - 234

Publisher

Wiley

Location

London, Eng.

eISSN

1476-5381

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, John Wiley & Sons

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