Deakin University
Browse
busija-youngersiblings-2013.pdf (149.52 kB)

Younger siblings, C-Reactive protein, and risk of age-related macular degeneration

Download (149.52 kB)
journal contribution
posted on 2013-01-01, 00:00 authored by A Cohn, Ljoudmila Busija, L Robman, P Dimitrov, M Varsamidis, L Lim, P Baird, R Guymer
In this study, we examined the relationship between exposure to siblings and 1) the risk of age-related macular degeneration (AMD) and 2) C-reactive protein levels. We retrospectively analyzed pooled cross-sectional data from 2 studies: the Cardiovascular Health and Age-Related Maculopathy Study (2001–2002) and the Age-Related Maculopathy Statin Study (2004–2006). Associations between number of siblings and AMD were assessed by using multinomial logistic regression. Associations between number of siblings and C-reactive protein levels were examined by using a generalized linear model for γ distribution. A higher number of younger siblings was associated with significantly lower odds of early AMD in those with a family history of AMD (odds ratio = 0.2, 95% confidence interval: 0.1, 0.8) (P = 0.022) but was unrelated to AMD for those who had no family history of the disease (odds ratio = 1.0, 95% confidence interval: 0.9, 1.2) (P = 0.874). A higher number of younger siblings correlated with lower C-reactive protein levels (β = −0.19, 95% confidence interval: −0.38, −0.01) (P = 0.036). This supports the theory that immune modulation contributes to AMD pathogenesis and suggests that exposure to younger siblings might be protective when there is a family history of AMD.

History

Journal

American Journal of Epidemiology

Volume

177

Issue

9

Pagination

933 - 943

Publisher

Oxford University Press

Location

Oxford, UK

ISSN

0002-9262

eISSN

1476-6256

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2013, Oxford University Press

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC