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Zebrafish Models of Paediatric Brain Tumours
journal contribution
posted on 2023-02-10, 05:11 authored by Faiza BasheerFaiza Basheer, Poshmaal DharPoshmaal Dhar, Rasika SamarasingheRasika SamarasinghePaediatric brain cancer is the second most common childhood cancer and is the leading cause of cancer-related deaths in children. Despite significant advancements in the treatment modalities and improvements in the 5-year survival rate, it leaves long-term therapy-associated side effects in paediatric patients. Addressing these impairments demands further understanding of the molecularity and heterogeneity of these brain tumours, which can be demonstrated using different animal models of paediatric brain cancer. Here we review the use of zebrafish as potential in vivo models for paediatric brain tumour modelling, as well as catalogue the currently available zebrafish models used to study paediatric brain cancer pathophysiology, and discuss key findings, the unique attributes that these models add, current challenges and therapeutic significance.
History
Journal
International Journal of Molecular SciencesVolume
23Article number
ARTN 9920Location
SwitzerlandPublisher DOI
ISSN
1661-6596eISSN
1422-0067Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
17Publisher
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Keywords
Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, MultidisciplinaryChemistrypaediatric brain cancerzebrafishanimal modelsPATIENT-DERIVED XENOGRAFTCENTRAL-NERVOUS-SYSTEMTARGETED GENE DISRUPTIONHUMAN CANCERCELL TRANSPLANTATIONPHIC31 INTEGRASEDRUG DISCOVERYREPORTER LINESEXPRESSIONGENOMEAnimalsBrain NeoplasmsHumansSurvival RateZebrafishNeurosciencesCancer5.1 Pharmaceuticals2 Aetiology5 Development of treatments and therapeutic interventions2.1 Biological and endogenous factorsNeurologicalChemical Sciences not elsewhere classifiedGeneticsBiological Sciences not elsewhere classified
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