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ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

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journal contribution
posted on 23.10.2002, 00:00 authored by M Jimenez, B Léger, K Canola, L Lehr, P Arboit, J Seydoux, Aaron RussellAaron Russell, J P Giacobino, P Muzzin, F Prietner
Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β1/β2/β3). To test this hypothesis, we generated β1/β2/β3-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, β-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.

History

Journal

FEBS letters

Volume

530

Issue

1-3

Pagination

37 - 40

Publisher

Elsevier BV

Location

Amsterdam, The Netherlands

ISSN

0014-5793

eISSN

1873-3468

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Federation of European Biochemical Societies