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A new role for apolipoprotein E in brain copper regulation

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posted on 2023-04-06, 05:35 authored by Bryce Thomas Blades

This study investigated the role of the Alzheimer's disease major risk factor protein ApoE in regulating cellular copper. The disease-associated variant, ApoE4 contributes to impaired copper regulation in brain cells, potentially explaining the disrupted copper balance in the diseased brain and the biochemical basis for the risk associated with ApoE4.

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328 p.

Open access

  • Yes

Language

English

Degree type

Doctorate

Degree name

Ph.D.

Copyright notice

All rights reserved

Editor/Contributor(s)

Sharon La Fontaine, Scott Ayton

Faculty

Faculty of Science Engineering and Built Environment

School

School of Life and Environmental Sciences

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