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Antigenic relationships between bluetongue virus serotypes as defined by monoclonal antibodies

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thesis
posted on 1992-01-01, 00:00 authored by Ph.D. White
Panels of monoclonal antibodies (MAbs) were generated to individual proteins of an Australian isolate of bluetongue virus (BTV) serotype 1 (VP2, VP3, VP5, VP6, NS1 and NS2). The number of individual epitopes and antigenic regions each panel defined were then determined. The simultaneous reaction of certain neutralization-resistant variants and heterologous serotyoes with several MAbs specific for such epitopes, resulted in low level virus neutralization.

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xxi, 277 leaves : ill. ; 30 cm.

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thesis

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thesis

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eng

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Thesis (Ph.D.)--Deakin University, 1992.

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Ph.D.

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Faculty of Science

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Engineering and Built Environment

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