Chelation and Radiolabelling of Epithelial Cell Adhesion Molecule(EpCAM) and Transferrin Targeting Aptamers

This research investigated the chelation and radiolabelling of epithelial cell adhesion molecule (EpCAM) aptamer (SYL3C) and transferrin (GS24) targeting aptamers. These were each chelated (with DOTA) and then radiolabelled with a radioisotope. The radioisotopes used were Lutetium-177 and Actinium-225. In-vitro experiments demonstrated these reached their target cancer cells, prostate cancer and astrocytoma, respectively.