Functionality determination and characterization of an angiogenesis-inhibiting fusion protein

Chakrabarti, Sanjukta

Functionality determination and characterization of an angiogenesis-inhibiting fusion protein

thesis

posted on 2016-09-01, 00:00 authored by Sanjukta Chakrabarti

Angiogenesis is a hallmark of cancer and VEGF is the most potent pro-angiogenic factor that stimulates angiogenesis in diseases including cancer, A recombinant anti-VEGF, Fc-fusion protein, VEGFR1(D1-D3)-Fc was developed and characterized. The protein demonstrated strong binding affinity to VEGF and anti-angiogenic functions in cell-based assays and animal model of cancer.

History

Pagination

xxxiii, 409 pages : illustrations, tables, graphs, some coloured

Open access

Yes

Material type

thesis

Resource type

thesis

Language

eng

Degree type

Research doctorate

Degree name

PhD

Copyright notice

Editor/Contributor(s)

J Kanwar Jagat, C Barrow

Faculty

Faculty of Science Engineering and Built Environment

School

School of Life and Environmental Sciences

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Keywords

cancer therapy angiogenesis vascular endothelial growth factor (VEGF)Pharmaceutical Sciences Molecular Targets Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

Functionality determination and characterization of an angiogenesis-inhibiting fusion protein

History

Pagination

Open access

Material type

Resource type

Language

Degree type

Degree name

Copyright notice

Editor/Contributor(s)

Faculty

School

Usage metrics

Categories

Keywords

Licence

Exports