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Identification of genes in the liver of Psammomys obesus associated with Type II diabetes

thesis
posted on 2000-01-01, 00:00 authored by Hayley. Snelling
Type II diabetes is characterised by hyperglycemia and disturbances of fat, carbohydrate and protein metabolism. It occurs mainly in adults, with obesity being the most modifiable risk factor. This project utilised the Israeli Sand Rat (Psammomys obesus) and some of the latest molecular biology technology including differential display, membrane microarray and real-time PCR to detect genes in the liver that may be associated with the development of Type II diabetes and/or obesity. This study showed calpain, a proteolytic inhibitor and calpastatin, its natural inhibitor to be disregulated in the liver during the diabetic state.

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[ix], 131 leaves ; 30 cm.

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thesis

Resource type

thesis

Language

eng

Notes

Thesis (M.Sc.)--Deakin University, Victoria, 2000.

Degree name

M.Sc.

Faculty

Faculty of Health

School

School of Health Sciences

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