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Ikaros gene family : characterisation of the 'atypical' Pegasus
thesisposted on 2010-01-01, 00:00 authored by Liza Bernadine John
Ikaros-related transcription factors are essential for adaptive immunity. Evolutionary analysis suggested derivation from a precursor similar to the 'atypical' Pegasus protein, and possibly related to invertebrate Hunchback. Pegasus was shown to regulate neural, gut and blood cell development in zebrafish, with Ikaros identified as one of several potential gene targets.