masaldan-investigatingmetal-2017.pdf (15.1 MB)
Investigating metal aberrations in cellular senescence
thesis
posted on 2017-06-01, 00:00 authored by S MasaldanThis study explored perturbations in iron and copper homeostasis in senescent cells that contribute to age-associated disease and dysfunction. Altered metal regulation was associated with impaired cellular autophagy and resulted in extreme resistance to ferroptosis, a novel iron mediated cell death process linked to various pathologies.
History
Pagination
xiii, 178 pages, plus appendices: illustrations graphs, some colouredOpen access
- Yes